Pharmacological therapy is used to prevent episodes of vomiting or to decrease their frequency and also to abort or attenuate episodes once they begin. Preventive medications are normally used in patients with more than a single episode of CVS per month. The mainstays of prophylactic therapy include the following:
- Cyproheptadine
- Amitriptyline
- Anticonvulsants such as topiramate, zonisamide, and levetiracetam
- Propranolol
- Phenobarbital
- Erythromycin
Medications used for aborting episodes include the following:
- Ondansetron
- Promethazine
- Prochlorperazine
- Triptans
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